Multi-sensitive curcumin-loaded nanomicelle based on ABC-CBA block copolymer for sustained drug delivery

A type of multi-sensitive ABC-CBA block copolymer with thermal, glutathione and pH-responsive bonds was synthesized via ring opening polymerization along cationic mechanisms. In continuum, the strands self-assembled into nanomicelles. The linear is comprised poly (methoxy ethylene glycol)-b-poly (2-ethyl-2-oxazoline)-b-poly (?-caprolactone)-cystamine (i.e. [mPEG-b-PEtOz-PCL]2-Cys) curcumin encapsulated inside micelles mostly through hydrophobic interaction. H-NMR, FTIR GPC analysis were applied to identify composition structure copolymer. critical micelle concentration (CMC) value achieved favorably 0.01 mg/mL for morphology particle size solid nanocarrier characterized by DLS, Zeta potential, AFM, TEM, SEM micrographs. drug loading content attained 13.3% (w/w), entrapment efficacy in obtained 79 percent. vitro release profile drug-loaded investigated exposure different pH, temperature reduction circumstances, stimulated tumor microenvironment conditions. cell viability assay demonstrates high cytotoxicity toward HDF cells, while drug-free has trifling toxicity good biocompatibility. Therefore, according pleasant output research, this novel nanomicelle based on can be carried out effectively as an efficient targeted delivery.